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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
20.3
Human Site:
S892
Identified Species:
31.9
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S892
K
I
L
K
Q
V
I
S
L
Q
T
K
N
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S892
K
I
L
K
Q
V
I
S
L
Q
T
K
N
P
E
Dog
Lupus familis
XP_531814
1283
145094
A853
T
G
L
I
T
P
K
A
G
F
D
S
D
Y
D
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
T889
K
T
L
K
Q
V
V
T
L
Q
S
K
S
P
K
Rat
Rattus norvegicus
XP_002726765
1361
151628
T892
K
T
L
K
Q
V
V
T
L
Q
T
K
S
P
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
T998
Q
V
L
K
Q
L
V
T
R
K
A
K
H
P
D
Frog
Xenopus laevis
NP_001089247
1340
149481
C872
S
I
L
K
Q
I
V
C
V
K
D
K
A
S
H
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
L893
K
L
L
R
Q
V
V
L
L
K
T
E
N
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
G767
G
V
I
A
P
Q
A
G
M
D
A
E
Y
D
A
Honey Bee
Apis mellifera
XP_392346
1120
127429
T697
E
S
L
D
Y
F
K
T
A
F
D
H
E
E
A
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
V763
A
M
K
D
G
K
I
V
P
N
A
G
C
D
E
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
S864
S
L
L
K
A
C
I
S
L
K
S
T
G
C
R
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
G857
K
E
Q
Q
K
L
L
G
D
K
S
I
T
Y
V
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
L846
K
H
D
T
S
R
R
L
L
H
L
L
T
P
G
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
D819
C
S
N
I
Q
Y
K
D
S
G
K
E
I
Y
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
60
66.6
N.A.
N.A.
33.3
33.3
46.6
N.A.
0
6.6
13.3
33.3
P-Site Similarity:
100
N.A.
100
26.6
N.A.
93.3
93.3
N.A.
N.A.
86.6
60
86.6
N.A.
26.6
20
20
53.3
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
20
6.6
N.A.
P-Site Similarity:
46.6
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
7
7
0
7
7
7
0
20
0
7
0
14
% A
% Cys:
7
0
0
0
0
7
0
7
0
0
0
0
7
7
0
% C
% Asp:
0
0
7
14
0
0
0
7
7
7
20
0
7
14
20
% D
% Glu:
7
7
0
0
0
0
0
0
0
0
0
20
7
14
20
% E
% Phe:
0
0
0
0
0
7
0
0
0
14
0
0
0
0
0
% F
% Gly:
7
7
0
0
7
0
0
14
7
7
0
7
7
0
7
% G
% His:
0
7
0
0
0
0
0
0
0
7
0
7
7
0
7
% H
% Ile:
0
20
7
14
0
7
27
0
0
0
0
7
7
0
0
% I
% Lys:
47
0
7
47
7
7
20
0
0
34
7
40
0
0
14
% K
% Leu:
0
14
67
0
0
14
7
14
47
0
7
7
0
0
0
% L
% Met:
0
7
0
0
0
0
0
0
7
0
0
0
0
0
0
% M
% Asn:
0
0
7
0
0
0
0
0
0
7
0
0
20
0
0
% N
% Pro:
0
0
0
0
7
7
0
0
7
0
0
0
0
40
0
% P
% Gln:
7
0
7
7
54
7
0
0
0
27
0
0
0
0
0
% Q
% Arg:
0
0
0
7
0
7
7
0
7
0
0
0
0
0
7
% R
% Ser:
14
14
0
0
7
0
0
20
7
0
20
7
14
7
0
% S
% Thr:
7
14
0
7
7
0
0
27
0
0
27
7
14
0
7
% T
% Val:
0
14
0
0
0
34
34
7
7
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
7
7
0
0
0
0
0
0
7
20
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _